Selected Publications

Eshaghi, B., Wang, E.Y., Mursalova, S., Forster, T.A., Lasrado, N., Tian, J., Artzi, D., Lin, S.Q., Wu, Z., Yang, X., Chung, W.T., Sadeghi, I., Garcia, J., Chen, Z., Sheridan, O., Das, R., Lau, A., Gurram, A., Mainou, B.A., Jones, K.A.V., Liu, Y., Barouch, D.H., von Andrian, U.H., Langer, R. and Jaklenec, A., 2026. Am80-lipid nanoparticles serve as an enteric mucosal adjuvant following parenteral immunization with inactivated polio vaccine. Science Advances 12(23), p.eaea5433.

Wang, E.Y., Calle, E.A., Ying, B., Eshaghi, B., Zhang, L., Yang, X., Lin, S.Q., Han, J., Backx, A.G., Huang, Y., Mursalova, S., Qi, C.J., Liu, Y., Langer, R. and Jaklenec, A., 2026. TIMED: Temporal intervention with microparticle encapsulation and delivery—A programmed release system for post-myocardial infarction therapy. Cell Biomaterials 2(1), p.100249.

Wang, E.Y., Sarmadi, M., Ying, B., Jaklenec, A. and Langer, R., 2023. Recent advances in nano- and micro-scale carrier systems for controlled delivery of vaccines. Biomaterials 303, p.122345.

Kuzmanov, U.*, Wang, E.Y.*(contributed equally), Vanderlaan, R., Kim, D.H., Lee, S.H., Hadipour-Lakmehsari, S., Guo, H., Zhao, Y., McFadden, M., Sharma, P., Billia, F., Radisic, M., Gramolini, A. and Emili, A., 2020. Mapping signalling perturbations in myocardial fibrosis via the integrative phosphoproteomic profiling of tissue from diverse sources. Nature Biomedical Engineering 4(9), pp.889–900

Wang E.Y., Rafatian N., Zhao Y., Lee A., Lai B.F.L., Lu X.Z., Jekic D., Davenport Huyer D., Bhattacharya S., Backx P.H., and Radisic M. Biowire model of interstitial and focal cardiac fibrosis. ACS Central Science. 2019; 5, 7, 1146–1158. 

Yang, X., Zhang, L., Chen, F., Gao, W., Zheng, Z., Wang, T., Wang, E.Y., Eshaghi, B., MacDonald, S., Langer, R. and Jaklenec, A., 2025. Ferrous nutritional metal-organic framework as food fortificant. Matter 8(10), p.102372.

Han, J., Kanelli, M., Liu, Y., Daristotle, J.L., Pardeshi, A., Forster, T.A., Karchin, A., Folk, B., Murmann, L., Tostanoski, L.H., Carrasco, S.E., Alsaiari, S.K., Wang, E.Y., Tran, K., Zhang, L., Eshaghi, B., Levy, L., Pyon, S., Sloane, C., Lin, S.Q., Lau, A., Perkinson, C.F., Bawendi, M.G., Barouch, D.H., Durand, F., Langer, R. and Jaklenec, A., 2025. On-patient medical record and mRNA therapeutics using intradermal microneedles. Nature Materials 24(5), pp.794–803.

Zhao Y*., Wang E.Y.* (contributed equally), Lai B.F.L., Cheung K., and Radisic M. Organs-on-a-chip: a union of tissue engineering and microfabrication. Trends in Biotechnology. 2023; 41(3): 410-424. 

Wang E.Y., Kuzmanov U., Smith J., Dou W., Rafatian N., Wu Q., Lai B.F.L., Lu X.Z., Yazbeck J., Sun Y., Gramolini A., and Radisic M. An organ-on-a-chip model of progressive remodeling in Angiotensin II induced cardiomyopathy and pre-clinical drug testing. Journal of Molecular and Cellular Cardiology. 2021;160:97-110.

Wu Q., Rafatian N., Wagner K.T., Blamer J., Smith J., Okhovatian S. , Aggarwal P., Wang E.Y., Banerjee A. , Zhao Y. , Lu X.Z.,, Esquivel L.P. , Li C.Y.,  Kuzmanov U., Mandla S. , Virlee E. , Landau S., Lai B.F.L, Gramolini A., Veres T., Vunjak-Novakovic G. , Zhang B. , Broeckel U, and Radisic M. Heart-on-a-chip platform to model cardiac SARS-CoV-2 pathogenesis and therapeutic screening. Proceedings of the National Academy of Sciences. 2024; 121 (28) e2403581121. 

Hamidzada H., Pascual-Gil S., Wu Q., Kent G., Atkins M., Massé S., Landau S., Gomez-Garcia J., Kantores C., Beroncal E., Rafatian N., Nanthakumar J., Wang E.Y., Sadikov T., Andreazza A., Nanthakumar K., Laflamme M., Keller G., Radisic M., and Epelman S. Primitive macrophages enhance the function of bioengineered human cardiac microtissues. Nature Cardiovascular Research. 2024; 3, 567-593.  

Alsaiari S.K., Nadeef S., Daristotle J.L., Rothwell W., Du B., Garcia J., Zhang L., Sarmadi M.,Forster T.A., Menon N., Lin S.Q, Tostanoski L.H., Hachmann N., Wang E.Y.,Ventura J.D., Barouch D.H., Langer R., and Jaklenec A. Zeolitic imidazolate frameworks activate endosomal toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer. Science Advances. 2024: 10,eadj6380. 

Kinnear C., Said A., Meng G., Zhao Y., Wang E.Y., Parmar N., Wei W., Billia F., Simmons C.A., Radisic M., Ellis J., and Mital S. Myosin inhibitor reverses hypertrophic cardiomyopathy in pediatric iPSC-cardiomyocytes to mirror variant correction. Cell Report Medicine. 2024; 5 (5): 101520. 

Lai B.F.L., Lu X.Z., Davenport Huyer D., Kakinoki S., Yazbeck J., Wang E.Y., Wu Q., Zhang B., and Radisic M. A 96-well based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature. Nature Protocol. 2021; 16(4):2158-2189.  

Lai B.F.L., Lu X.Z., Hu Y.S., Davenport Huyer D., Dou W, Wang E.Y., Radulovich N, Tsao M.S., Sun Y., and Radisic M. Recapitulating Pancreatic Tumor Microenvironment through Synergistic Use of Patient Organoids and Organ-on-a-Chip Vasculature. Advanced Functional Materials. 2020; 30, 2000545. 

Zhao Y., Rafatian N., Feric N., Aschar-Sobbi R., COX B.J., Wang E.Y., Zhang B., Conant G., Ronaldson K., Keller G., Vunjak-Novakovic G., Backx P., and Radisic M. A platform for generation of chamber-specific cardiac tissues and disease modeling. Cell. 2019; 176, 913–927.  

Zhao Y., Wang E.Y., Davenport-Huyer L., Vunjak-Novakovic G., Radisic M., and Zhang B. Rapid casting of micro-wires enabled high-throughput production of functional tissues. Advanced Healthcare Materials. 2019; 8, 1801187.